Search results for "Nanotubes de titanate"
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Synthèses optimisées et caractérisations avancées de nanotubes de titanate et de leurs fonctionnalisations : vers l'élaboration de nanovecteurs de mo…
2017
The aim of this PhD thesis is to develop new nanohybrids based on titanate nanotubes (TiONts) in order to use them as nanocarrier of a therapeutic molecule: a stilbene phenol, 4'-hydroxy-4-(3-aminopropoxy)-trans-stilbene (HAPtS), which is a transresveratrol derivative.TiONts are synthesized by a hydrothermal treatment from a precursor of rutile titanium dioxide. Two methods of hydrothermal synthesis have been studied (the static and dynamic ones): the second approach uses an original hydrothermal device which provides a vigorous mechanical stirring during the hydrothermal process with controllable stirring time par hour. A parametric study was carried out to evaluate the effect of reaction …
Titanate nanotubes as versatile nanovectors : radiosensitizers for the treatment of prostate cancer and nuclear imaging probes
2017
Currently, the systemic injections of drugs reach very weakly tumor sites and large doses are thus administered causing adverse side effects. The new implementations of nanoparticles in the medical field offer new strategies to vectorize an active substance in diseased cells. This work is focused on the prostate cancer, which is the second most frequently diagnosed cancer and the fifth leading cause of cancer death in men worldwide.Titanate nanotubes (TiONts) are synthetized by a hydrothermal process and have average dimensions of about 170 nm in length, 10 nm in outer diameter and also have an internal cavity of 4 nm in diameter. Their needle-shaped morphology allows them to be internalize…
Iron oxides nanoparticles and titanate nanotubes dedicated to multimodal imaging and anticancer therapy
2013
The new implementations of nanoparticles in the medical field are one of the essential factors of the medical progress expected at the beginning of this XXIst century. Thus, the domain of the medical imaging is also affected by this technological evolution. This work consisted in developing theranostic probes with iron oxides nanoparticles (SPIO) and titanate nanotubes (TiONts) for multimodal imaging (magnetic/nuclear or magnetic/optical) and also possessing a therapeutic effect (hyperthermia/PDT or radiosensitization/PDT).The titanate nanotubes of this study have an average length of about 150 nm and were obtained by Kasuga's hydrothermal synthesis. These nanotubes present an outside diame…